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Can We Predict Clinical Cardiotoxicity with Cardiac Biomarkers in Patients After Haematopoietic Stem Cell Transplantation?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00061214" target="_blank" >RIV/00159816:_____/15:00061214 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s12012-014-9286-7" target="_blank" >http://dx.doi.org/10.1007/s12012-014-9286-7</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s12012-014-9286-7" target="_blank" >10.1007/s12012-014-9286-7</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Can We Predict Clinical Cardiotoxicity with Cardiac Biomarkers in Patients After Haematopoietic Stem Cell Transplantation?

  • Original language description

    The long-term prognosis of patients after haematopoietic stem cell transplantation (HSCT) has greatly improved. Cardiac complications represent unresolved and potentially life-threatening conditions in these patients. We prospectively examined 37 consecutive patients with a median age of 28 years who underwent allogeneic HSCT. Biomarkers of cardiac injury were measured serially before the conditioning regimen, the first day after HSCT and then 14, 30, 90 and 180 days after HSCT. Echocardiography was performed before and 1 month after HSCT. Eleven patients (30 %) had persistently increased NT-proBNP values, 14 patients (38 %) had only transient elevations and 12 (32 %) had no changes in NT-proBNP concentrations for a period exceeding 14 days after HSCT.Elevated NT-proBNP values at day 14 after HSCT remained an independent predictor of cardiotoxicity during the first 6 months after HSCT (P < 0.01). Patients with persistent elevations in NT-proBNP also had significant elevations in hs-cT

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cardiovascular Toxicology

  • ISSN

    1530-7905

  • e-ISSN

  • Volume of the periodical

    15

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    210-216

  • UT code for WoS article

    000355776300002

  • EID of the result in the Scopus database