Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00062860" target="_blank" >RIV/00159816:_____/15:00062860 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/15:43873477 RIV/62157124:16370/15:43873477
Result on the web
<a href="http://dx.doi.org/10.1016/j.fitote.2015.01.012" target="_blank" >http://dx.doi.org/10.1016/j.fitote.2015.01.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fitote.2015.01.012" target="_blank" >10.1016/j.fitote.2015.01.012</a>

Result language
angličtina
Original language name
Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats
Original language description
Diplacone (1) and mimulone (2), two geranylated flavanones, have previously shown anti-inflammatory and antiradical activity in vitro. The present study aimed to evaluate their activity in vivo on a model of colitis induced in Wistar rats by an oral administration of dextran sulfate sodium (DSS). Diplacone (1) and mimulone (2) were administered at a bolus dose of 25 mg/kg by gastric gavage 48 and 24 h prior to the induction of colitis by DSS and every 24 h on the following days of the experiment The effect of the treatment was assessed by Monitoring the disease activity index (DAI), histopathological examination, evaluation of the weight and length of the colon and by analysis of the levels and activities of cyclooxygenase-2 (COX-2), matrix metalloproteinase-2 (MMP2), superoxide dismutase-2 (SOD2), and catalase (CAT) in the inflamed tissue. Administration of the test compounds prior and after induction of colitis ameliorated the symptoms of colitis (diarrhea, presence of the blood in t
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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