Instability restricts signaling of multiple fibroblast growth factors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00062877" target="_blank" >RIV/00159816:_____/15:00062877 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/15:00445257 RIV/67985904:_____/15:00445257 RIV/00216224:14110/15:00080926 RIV/62157124:16170/15:43873501
Result on the web
<a href="http://dx.doi.org/10.1007/s00018-015-1856-8" target="_blank" >http://dx.doi.org/10.1007/s00018-015-1856-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00018-015-1856-8" target="_blank" >10.1007/s00018-015-1856-8</a>
Alternative languages
Result language
angličtina
Original language name
Instability restricts signaling of multiple fibroblast growth factors
Original language description
Fibroblast growth factors (FGFs) deliver extracellular signals that govern many developmental and regenerative processes, but the mechanisms regulating FGF signaling remain incompletely understood. Here, we explored the relationship between intrinsic stability of FGF proteins and their biological activity for all 18 members of the FGF family. We report that FGF1, FGF3, FGF4, FGF6, FGF8, FGF9, FGF10, FGF16, FGF17, FGF18, FGF20, and FGF22 exist as unstable proteins, which are rapidly degraded in cell cultivation media. Biological activity of FGF1, FGF3, FGF4, FGF6, FGF8, FGF10, FGF16, FGF17, and FGF20 is limited by their instability, manifesting as failure to activate FGF receptor signal transduction over long periods of time, and influence specific cell behavior in vitro and in vivo. Stabilization via exogenous heparin binding, introduction of stabilizing mutations or lowering the cell cultivation temperature rescues signaling of unstable FGFs. Thus, the intrinsic ligand instability is an important elementary level of regulation in the FGF signaling system.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cellular and Molecular Life Sciences
ISSN
1420-682X
e-ISSN
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Volume of the periodical
72
Issue of the periodical within the volume
12
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
2445-2459
UT code for WoS article
000354883500014
EID of the result in the Scopus database
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