Ligand bias underlies differential signaling of multiple FGFs via FGFR1
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00585091" target="_blank" >RIV/67985904:_____/24:00585091 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00136112 RIV/00159816:_____/24:00081460
Result on the web
<a href="https://elifesciences.org/articles/88144" target="_blank" >https://elifesciences.org/articles/88144</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7554/eLife.88144" target="_blank" >10.7554/eLife.88144</a>
Alternative languages
Result language
angličtina
Original language name
Ligand bias underlies differential signaling of multiple FGFs via FGFR1
Original language description
The differential signaling of multiple FGF ligands through a single fibroblast growth factor (FGF) receptor (FGFR) plays an important role in embryonic development. Here, we use quantitative biophysical tools to uncover the mechanism behind differences in FGFR1c signaling in response to FGF4, FGF8, and FGF9, a process which is relevant for limb bud outgrowth. We find that FGF8 preferentially induces FRS2 phosphorylation and extracellular matrix loss, while FGF4 and FGF9 preferentially induce FGFR1c phosphorylation and cell growth arrest. Thus, we demonstrate that FGF8 is a biased FGFR1c ligand, as compared to FGF4 and FGF9. Forster resonance energy transfer experiments reveal a correlation between biased signaling and the conformation of the FGFR1c transmembrane domain dimer. Our findings expand the mechanistic understanding of FGF signaling during development and bring the poorly understood concept of receptor tyrosine kinase ligand bias into the spotlight.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
eLife
ISSN
2050-084X
e-ISSN
2050-084X
Volume of the periodical
12
Issue of the periodical within the volume
Apr 3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
28
Pages from-to
RP88144
UT code for WoS article
001196755600001
EID of the result in the Scopus database
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