Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00597897" target="_blank" >RIV/67985904:_____/24:00597897 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00137051 RIV/00159816:_____/24:00081491
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1359610124000443?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1359610124000443?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cytogfr.2024.07.002" target="_blank" >10.1016/j.cytogfr.2024.07.002</a>

Result language
angličtina
Original language name
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands
Original language description
The FGF system is the most complex of all receptor tyrosine kinase signaling networks with 18 FGF ligands and four FGFRs that deliver morphogenic signals to pattern most embryonic structures. Even when a single FGFR is expressed in the tissue, different FGFs can trigger dramatically different biological responses via this receptor. Here we show both quantitative and qualitative differences in the signaling of one of the FGF receptors, FGFR1c, in response to different FGFs. We provide an overview of the recent discovery that FGFs engage in biased signaling via FGFR1c. We discuss the concept of ligand bias, which represents qualitative differences in signaling as it is a measure of differential ligand preferences for different downstream responses. We show how FGF ligand bias manifests in functional data in cultured chondrocyte cells. We argue that FGF-ligand bias contributes substantially to FGF-driven developmental processes, along with known differences in FGF expression levels, FGF-FGFR binding coefficients and differences in FGF stability in vivo.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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