Role of Peptide YY in blood vessel function and atherosclerosis in a rabbit model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00062967" target="_blank" >RIV/00159816:_____/15:00062967 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/1440-1681.12398" target="_blank" >http://dx.doi.org/10.1111/1440-1681.12398</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/1440-1681.12398" target="_blank" >10.1111/1440-1681.12398</a>
Alternative languages
Result language
angličtina
Original language name
Role of Peptide YY in blood vessel function and atherosclerosis in a rabbit model
Original language description
Cardiovascular disease remains a burden for Westernized countries. Peptide YY (PYY) raises blood pressure, yet its role has not yet been determined in diseased arteries. This study was aimed at identifying PYY and eNOS in diseased blood vessels and to determine which blood vessels respond to PYY. New Zealand White rabbits were fed an atherogenic diet (n=3, 0.5% cholesterol +1% methionine + 5% peanut oil) and control animals fed a normal diet (n=3) for 4 weeks. Immunohistochemistry was used to determinethe localisation of PYY and eNOS in aorta. The aorta, carotid, renal, iliac, inferior mesenteric, and renal interlobular arteries were removed, mounted in organ baths, and subjected to doses of PYY (10-9-10-7M) and then acetylcholine (10-6M). Immunohistochemistry of aorta shows PYY staining in plaque macrophages, smooth muscle cells and endothelium, and these cells co-expressed eNOS. PYY caused a minor vasoconstrictive response in all blood vessels studied but was blunted in arteries fro
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical and Experimental Pharmacology and Physiology
ISSN
1440-1681
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
648-652
UT code for WoS article
000355878500013
EID of the result in the Scopus database
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