Activation of TGF-beta Receptors and Smad Proteins by Atorvastatin is Related to Reduced Atherogenesis in ApoE/LDLR Double Knockout Mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F12%3A10124885" target="_blank" >RIV/00216208:11150/12:10124885 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/12:10124885
Result on the web
<a href="https://www.jstage.jst.go.jp/article/jat/19/2/19_8185/_pdf" target="_blank" >https://www.jstage.jst.go.jp/article/jat/19/2/19_8185/_pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5551/jat.8185" target="_blank" >10.5551/jat.8185</a>

Result language
angličtina
Original language name
Activation of TGF-beta Receptors and Smad Proteins by Atorvastatin is Related to Reduced Atherogenesis in ApoE/LDLR Double Knockout Mice
Original language description
Aim: Transforming growth factor-beta (TGF-beta) plays important role in atherogenesis via TGF-beta receptors and Smad proteins, which determine its signaling activity. In this study, we hypothesized, whether non-lipid related effects of atorvastatin, affect both endoglin/ALK-5/Smad2/eNOS and/or endoglin/ALK-1/Smad1/VEGF previously proposed pathways in ApoE/LDLR double knockout mice. Methods: ApoE/LDLR double knockout mice were divided into two groups. The chow group (CHOW) (n = 8) was fed with chow diet, while in the atorvastatin group (ATV) (n = 8) atorvastatin was added to the chow diet at dose 50 mg/kg/day. Biochemical analyses of lipid profile, lesion area measurement, immunohistochemistry and Western blot analysis of endoglin, ALK-1, 5, phosphorylated and non-phosphorylated forms Smad-1, 2, VEGF and eNOS proteins in mice aorta were performed. Results: Biochemical analysis of blood serum and morphometric analysis of aortic lesion size showed that atorvastatin treatment resulted in
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
—

Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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