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Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10100653" target="_blank" >RIV/00216208:11150/11:10100653 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/11:10100653 RIV/00179906:_____/11:10100653

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S1043661811000727" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1043661811000727</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.phrs.2011.03.008" target="_blank" >10.1016/j.phrs.2011.03.008</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis

  • Original language description

    In this study, we hypothesized whether atorvastatin treatment affects endoglin/ALK-1/p-Smad1/VEGF expression in the aorta and endoglin levels in serum in ApoE/LDLR double knockout mice. In conclusion, it has been demonstrated that atorvastatin increasesendoglin/ALK-1/p-Smad1/VEGF expression in aorta and decreases the size of atherosclerotic lesions, suggesting that activation of this endothelial-protective pathway might support the antiatherogenic effects of atorvastatin. Moreover, atorvastatin concurrently decreased serum levels of endoglin suggesting that monitoring of endoglin levels in blood might represent an important marker of the progression and/or treatment of atherosclerosis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pharmacological Research

  • ISSN

    1043-6618

  • e-ISSN

  • Volume of the periodical

    64

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    IT - ITALY

  • Number of pages

    7

  • Pages from-to

    53-59

  • UT code for WoS article

    000291907900008

  • EID of the result in the Scopus database