Cholesterol Effects on Endoglin and Its Downstream Pathways in ApoE/LDLR Double Knockout Mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10100649" target="_blank" >RIV/00216208:11150/11:10100649 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/11:10100649 RIV/00179906:_____/11:10100649
Result on the web
<a href="http://www.jstage.jst.go.jp/article/circj/75/7/1747/_pdf" target="_blank" >http://www.jstage.jst.go.jp/article/circj/75/7/1747/_pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1253/circj.CJ-10-1285" target="_blank" >10.1253/circj.CJ-10-1285</a>
Alternative languages
Result language
angličtina
Original language name
Cholesterol Effects on Endoglin and Its Downstream Pathways in ApoE/LDLR Double Knockout Mice
Original language description
The aim of the study was to evaluate whether cholesterol-rich diet affects transforming growth factor-beta-RIII (endoglin) levels in blood and 2 endoglin-related pathways in the aorta of ApoE/LDLR double knockout mice. Hypercholesterolemia increases endoglin levels in blood and simultaneously decreases its expression in aorta, together with atherosclerosis protective markers p-Smad2 and VEGF, followed by increased plaque size. Inhibition of endoglin signaling might be one of the mechanisms responsible for the promoting of endothelial dysfunction and atherogenesis. Moreover, the monitoring of endoglin serum levels might represent an attractive blood marker of progression of disease; however, the precise source and role of endoglin in blood serum remainsto be elucidated.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Circulation Journal
ISSN
1346-9843
e-ISSN
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Volume of the periodical
75
Issue of the periodical within the volume
7
Country of publishing house
JP - JAPAN
Number of pages
9
Pages from-to
1747-1755
UT code for WoS article
000292342600034
EID of the result in the Scopus database
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