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Cholesterol Effects on Endoglin and Its Downstream Pathways in ApoE/LDLR Double Knockout Mice

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10100649" target="_blank" >RIV/00216208:11150/11:10100649 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/11:10100649 RIV/00179906:_____/11:10100649

  • Result on the web

    <a href="http://www.jstage.jst.go.jp/article/circj/75/7/1747/_pdf" target="_blank" >http://www.jstage.jst.go.jp/article/circj/75/7/1747/_pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1253/circj.CJ-10-1285" target="_blank" >10.1253/circj.CJ-10-1285</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cholesterol Effects on Endoglin and Its Downstream Pathways in ApoE/LDLR Double Knockout Mice

  • Original language description

    The aim of the study was to evaluate whether cholesterol-rich diet affects transforming growth factor-beta-RIII (endoglin) levels in blood and 2 endoglin-related pathways in the aorta of ApoE/LDLR double knockout mice. Hypercholesterolemia increases endoglin levels in blood and simultaneously decreases its expression in aorta, together with atherosclerosis protective markers p-Smad2 and VEGF, followed by increased plaque size. Inhibition of endoglin signaling might be one of the mechanisms responsible for the promoting of endothelial dysfunction and atherogenesis. Moreover, the monitoring of endoglin serum levels might represent an attractive blood marker of progression of disease; however, the precise source and role of endoglin in blood serum remainsto be elucidated.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Circulation Journal

  • ISSN

    1346-9843

  • e-ISSN

  • Volume of the periodical

    75

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    JP - JAPAN

  • Number of pages

    9

  • Pages from-to

    1747-1755

  • UT code for WoS article

    000292342600034

  • EID of the result in the Scopus database