Polymorphisms of inflammatory markers and risk of essential hypertension in Tatars from Russia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00063199" target="_blank" >RIV/00159816:_____/15:00063199 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10641963.2014.987394" target="_blank" >http://dx.doi.org/10.3109/10641963.2014.987394</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10641963.2014.987394" target="_blank" >10.3109/10641963.2014.987394</a>
Alternative languages
Result language
angličtina
Original language name
Polymorphisms of inflammatory markers and risk of essential hypertension in Tatars from Russia
Original language description
Essential hypertension (EH) is a common disease with a clear genetic component. Inflammation and endothelial dysfunction play a prominent role in the development of persistent blood pressure elevation. The aim of the current study was to detect an association between EH and polymorphic markers in genes encoding for molecules involved in the control of intercellular interactions during the inflammation process. We analysed SNPs in SELE, SELP, SELL, ICAM1, VEGFA, IL1B, IL6, IL10 and IL12B genes in a groupof 534 men of Tatar ethnicity (217 patients with EH and 317 controls). Using a Markov chain Monte-Carlo-based approach (APSampler), we found genotype and allelic combinations associated with EH. The most significant associations were observed for SELE rs2076059*C-SELP rs6131*A-VEGFA -2549*I-IL1B rs16944*C (p = 3.42 x 10(-5), FDR q = 0.035) and SELE rs2076059*C-SELP rs6131*A-IL12B rs3212227*C-IL1B rs16944*C (p = 323 x 10(-4), FDR q = 0.035).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical and Experimental Hypertension
ISSN
1064-1963
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
398-403
UT code for WoS article
000359846700009
EID of the result in the Scopus database
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