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Genotype/allelic combinations as potential predictors of myocardial infarction

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00100499" target="_blank" >RIV/00216224:14110/16:00100499 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s11033-015-3933-3" target="_blank" >http://dx.doi.org/10.1007/s11033-015-3933-3</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s11033-015-3933-3" target="_blank" >10.1007/s11033-015-3933-3</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Genotype/allelic combinations as potential predictors of myocardial infarction

  • Original language description

    In order to find new informative predictors of myocardial infarction, we performed an analysis of genotype frequencies of polymorphic markers of SELE (rs2076059, 3832T &gt; C), SELP (rs6131, S290 N), SELL (rs1131498, F206L), ICAM1 (rs5498, K469E), VCAM1 (rs3917010, c.928 + 420A &gt; C), PECAM1 (rs668, V125L), VEGFA (rs35569394, -2549(18)I/D), CCL2 (rs1024611, -2518A &gt; G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c.303 + 30998A &gt; G) genes in the group of Russian men with myocardial infarction (N = 315) and the control group of corresponding ethnicity, gender, and age (N = 286). Using Markov chain Monte-Carlo method (APSampler), we found genotype combinations associated with increased and decreased risk of myocardial infarction. The most significant associations were detected for PECAM1*V/V + DDAH1*C (OR = 4.17 CI 1.56-11.15 P-perm = 0.005) SELE*C + VEGFA*I + CCL2*G + VCAM1*A + NOS3*D (OR = 2.74 CI 1.66-4.52 P-perm = 2.09 x 10(-5)), and VEGFA*D/D + CCL2*A + DDAH1*C (OR = 0.44 CI 0.28-0.7 P-perm = 7.89 x 10(-5)) genotype combinations.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    MOLECULAR BIOLOGY REPORTS

  • ISSN

    0301-4851

  • e-ISSN

  • Volume of the periodical

    43

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    6

  • Pages from-to

    11-16

  • UT code for WoS article

    000368063700002

  • EID of the result in the Scopus database