Does proteasome regulate the level of microRNA-1 in cardiomyocytes? Application to anoxia-reoxygenation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00063204" target="_blank" >RIV/00159816:_____/15:00063204 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s11010-015-2365-7" target="_blank" >http://dx.doi.org/10.1007/s11010-015-2365-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11010-015-2365-7" target="_blank" >10.1007/s11010-015-2365-7</a>
Alternative languages
Result language
angličtina
Original language name
Does proteasome regulate the level of microRNA-1 in cardiomyocytes? Application to anoxia-reoxygenation
Original language description
Proteasome and microRNAs play a critical role in almost all processes in a living organism, including pathology of the heart; however, their interaction is still in question. In the present study, we have found that proteasome inhibitor provoked increaseof mature but not immature microRNA-1 in cultured cardiomyocytes, and tested the hypothesis that mature microRNA-1 can be a substrate for endonuclease activity of proteasome. In our in vitro experiments, we have found that proteasome fraction II is ableto degrade both mature and primary but not precursor microRNA-1. However, this in vitro effect was not abolished by chemical inhibitor of proteolytic activities of proteasome. These data let us summarize that proteasome has the complex effect on the level of microRNA-1.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Cellular Biochemistry
ISSN
0300-8177
e-ISSN
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Volume of the periodical
404
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
45-51
UT code for WoS article
000355433900007
EID of the result in the Scopus database
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