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The case for dosing dabigatran: how tailoring dose to patient renal function, weight and age could improve the benefit-risk ratio

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00064386" target="_blank" >RIV/00159816:_____/15:00064386 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1177/1756285615601360" target="_blank" >http://dx.doi.org/10.1177/1756285615601360</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1177/1756285615601360" target="_blank" >10.1177/1756285615601360</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The case for dosing dabigatran: how tailoring dose to patient renal function, weight and age could improve the benefit-risk ratio

  • Original language description

    Dabigatran is increasingly being used in clinical practice for the thromboprophylaxis in atrial fibrillation as a convenient therapy that needs no drug level monitoring. However, analysis of the data of the same clinical trial that led to the adoption ofdabigatran in fixed-dosing regimens has indicated a small subgroup of patients that could be either over-treated, risking bleeding, or under-treated, risking embolism. Additional post-marketing data lends support to the favorable therapeutic profile ofdabigatran but at the same time raises doubts about patient characteristics such as weight, age, renal function and their pharmacokinetic effects that, in some cases, could be serious enough to expose a minority of patients to risk. We will present a clinical case of a patient with an ischemic stroke while on dabigatran that was found with low dabigatran plasma levels and we will discuss the currently available data on the effects of inherent patient characteristics on dabigatran pharmac

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Therapeutic Advances in Neurological Disorders

  • ISSN

    1756-2856

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    245-254

  • UT code for WoS article

    000364159600001

  • EID of the result in the Scopus database