Repeated Administration of Idarucizumab to a Patient with Dabigatran Overdose

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10373593" target="_blank" >RIV/00216208:11140/18:10373593 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/18:10373593

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Repeated Administration of Idarucizumab to a Patient with Dabigatran Overdose

Original language description

Idarucizumab is designed to reverse the anticoagulant effect of dabigatran. This case report describes the administration of three independent doses of idarucizumab to a 76-year-old man suffering from atrial flutter being treated with dabigatran to prevent ischaemic stroke. The last dose of dabigatran was administered in the morning of the same day the patient was transferred to hospital because of the need for urgent pericardium puncture. Baseline dTT (dilute thrombin time) reached 700 ng/mL as glomerular filtration (GF) dropped to 0.19 mL/s. The first dose of idarucizumab was administered prior to puncture and the clinical state was stabilized for the next 24 hours although dTT climbed to 400 ng/mL. The need for cannulation before dialysis required a second dose of antidote and a third dose was given prior to removal of the pericardium drain. Monitoring of dabigatran recovery showed that the reverse effect of idarucizumab lasted 12 hours, which is sufficiently long and reliable for urgent situations. Idarucizumab administration is not limited by age and/or renal impairment. We recommend repeated dTT examinations when the dabigatran baseline level exceeds 200 ng/mL and the antidote has been administered.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30205 - Hematology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Hamostaseologie

ISSN

0720-9355

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

4

Pages from-to

39-42

UT code for WoS article

000427065600007

EID of the result in the Scopus database

2-s2.0-85052706874