Analysis of lipophilic fluorescent products in blood of Alzheimer's disease patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00064229" target="_blank" >RIV/00159816:_____/16:00064229 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10332557 RIV/00064203:_____/16:10332557
Result on the web
<a href="http://dx.doi.org/10.1111/jcmm.12824" target="_blank" >http://dx.doi.org/10.1111/jcmm.12824</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jcmm.12824" target="_blank" >10.1111/jcmm.12824</a>
Alternative languages
Result language
angličtina
Original language name
Analysis of lipophilic fluorescent products in blood of Alzheimer's disease patients
Original language description
Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized by cognitive decline. Prodromal stage of AD, also called mild cognitive impairment (MCI), especially its amnestic type (aMCI), precedes dementia stage of AD. There are currently no reliable diagnostic biomarkers of AD in the blood. Alzheimer's disease is accompanied by increased oxidative stress in brain, which leads to oxidative damage and accumulation of free radical reaction end-products. In our study, specific products of lipid peroxidation in the blood of AD patients were studied. Lipophilic extracts of erythrocytes (AD dementia = 19, aMCI = 27, controls = 16) and plasma (AD dementia = 11, aMCI = 17, controls = 16) were analysed by fluorescence spectroscopy. The level of these products is significantly increased in erythrocytes and plasma of AD dementia and aMCI patients versus controls. We concluded that oxidative stress end-products are promising new biomarkers of AD, but further detailed characterisation of these products is needed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular and Molecular Medicine
ISSN
1582-4934
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
1367-1372
UT code for WoS article
000383587800016
EID of the result in the Scopus database
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