The lipid peroxidation products as possible markers of Alzheimer's disease in blood

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A8125" target="_blank" >RIV/00216208:11110/11:8125 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/11:6957 RIV/00064165:_____/11:8125

Result on the web

<a href="http://dx.doi.org/10.1016/j.exger.2010.09.015" target="_blank" >http://dx.doi.org/10.1016/j.exger.2010.09.015</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The lipid peroxidation products as possible markers of Alzheimer's disease in blood

Original language description

Oxidative stress, which is present in Alzheimer's disease (AD), results in the formation of various end-products of free radical reactions with proteins and lipids. At present there are no reliable diagnostic biomarkers of AD in the blood. Therefore, specific products of lipid peroxidation in the blood of AD patients were investigated. Lipophilic extracts of erythrocytes in the group of patients with AD (n = 44) and age-matched controls (n = 16) were studied. The end-products of lipid peroxidation, so called lipofuscin-like pigments (LFP), were analysed by fluorescence spectroscopy. It was found that the level of these products is significantly increased in erythrocytes of AD patients compared to controls. LFP were further separated by means of HPLC into individual fractions to study their composition in AD and controls. The specific fraction of LFP in AD patients, which was isolated, might represent a disease-specific product in the blood.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Gerontology

ISSN

0531-5565

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

38-42

UT code for WoS article

000286542800006

EID of the result in the Scopus database

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