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Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065210" target="_blank" >RIV/00159816:_____/16:00065210 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s13105-016-0476-6" target="_blank" >http://dx.doi.org/10.1007/s13105-016-0476-6</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s13105-016-0476-6" target="_blank" >10.1007/s13105-016-0476-6</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas

  • Original language description

    The prevalence of non-alcoholic fatty pancreas disease (NAFPD) is increasing in parallel with obesity rates. Stress-related alterations in endoplasmic reticulum (ER), such as the unfolded protein response (UPR), are associated with obesity. The aim of this study was to investigate ER imbalance in the pancreas of a mice model of adult and perinatal diet-induced obesity. Twenty female C57BL/6J mice were assigned to control (Con) or obesogenic (Ob) diets prior to and during pregnancy and lactation. Their offspring were weaned onto Con or Ob diets up to 6 months post-partum. Then, after sacrifice, plasma biochemical analyses, gene expression, and protein concentrations were measured in pancreata. Offspring of Ob-fed mice had significantly increased body weight (p < 0.001) and plasma leptin (p < 0.001) and decreased insulin (p < 0.01) levels. Maternal obesogenic diet decreased the total and phosphorylated Eif2 alpha and increased spliced X-box binding protein 1 (XBP1). Pancreatic gene expression of downstream regulators of UPR (EDEM, homocysteine-responsive endoplasmic reticulum-resident (HERP), activating transcription factor 4 (ATF4), and C/EBP homologous protein (CHOP)) and autophagy-related proteins (LC3BI/LC3BII) were differently disrupted by obesogenic feeding in both mothers and offspring (from p < 0.1 to p < 0.001). Maternal obesity and Ob feeding in their offspring alter UPR in NAFPD, with involvement of proapoptotic and autophagy-related markers. Upstream and downstream regulators of PERK, IRE1 alpha, and ATF6 pathways were affected differently following the obesogenic insults.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Physiology and Biochemistry

  • ISSN

    1138-7548

  • e-ISSN

  • Volume of the periodical

    72

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    ES - SPAIN

  • Number of pages

    11

  • Pages from-to

    281-291

  • UT code for WoS article

    000376479400013

  • EID of the result in the Scopus database