Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065619" target="_blank" >RIV/00159816:_____/16:00065619 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00088890 RIV/00216305:26620/16:PU120389 RIV/62156489:43210/16:43909557
Result on the web
<a href="http://dx.doi.org/10.1007/s13277-015-4569-6" target="_blank" >http://dx.doi.org/10.1007/s13277-015-4569-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13277-015-4569-6" target="_blank" >10.1007/s13277-015-4569-6</a>

Result language
angličtina
Original language name
Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC
Original language description
Approximately 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and the overall 5-year survival rate is not higher than 50 %. There is much evidence that human papillomavirus (HPV) infection may influence the expression of commonly studied HNSCC markers. Our study was focused on the possible HPV-specificity of molecular markers that could be key players in important steps of cancerogenesis (MKI67, EGF, EGFR, BCL-2, BAX, FOS, JUN, TP53, MT1A, MT2A, VEGFA, FLT1, MMP2, MMP9, and POU5F). qRT-PCR analysis of these selected genes was performed on 74 biopsy samples of tumors from patients with histologically verified HNSCC (22 HPV-, 52 HPV+). Kaplan-Meier analysis was done to determine the relevance of these selected markers for HNSCC prognosis. In conclusion, our study confirms the impact of HPV infection on commonly studied HNSCC markers MT2A, MMP9, FLT1, VEGFA, and POU5F that were more highly expressed in HPV-negative HNSCC patients and also shows the relevance of studied markers in HPV-positive and HPV-negative HNSCC patients.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NT14337" target="_blank" >NT14337: Study and characterization of tumour cell lines of primary squamous cell carcinoma of the head and neck and their malignant potential.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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