Prognostic significance of the tumour-adjacent tissue in head and neck cancers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43908490" target="_blank" >RIV/62156489:43210/15:43908490 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/15:PU118473 RIV/00159816:_____/15:00063981 RIV/00216224:14110/15:00087480
Result on the web
<a href="http://dx.doi.org/10.1007/s13277-015-3755-x" target="_blank" >http://dx.doi.org/10.1007/s13277-015-3755-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13277-015-3755-x" target="_blank" >10.1007/s13277-015-3755-x</a>
Alternative languages
Result language
angličtina
Original language name
Prognostic significance of the tumour-adjacent tissue in head and neck cancers
Original language description
Even with significant advances in operative skills and adjuvant therapies, the overall survival of patients suffering with head and neck squamous cancers (HNSCC) is unsatisfactory. Accordingly, no clinically useful prognostic biomarkers have been found yet for HNSCC. Many studies analysed the expression of potential markers in tumour tissues compared to adjacent tissues. Nevertheless, due to the sharing of the same microenvironment, adjacent tissues show molecular similarity to tumour tissues. Thus, gene expression patterns of 94 HNSCC tumorous tissues were compared with 31 adjacent tissues and with 10 tonsillectomy specimens of non-cancer individuals. The genes analysed at RNA level using quantitative RT-PCR and correlated with clinico-pathological conditions were as follows: EGF, EGFR, MKI67, BCL2, BAX, FOS, JUN, TP53, VEGF, FLT1, MMP2, MMP9, MT1A and MT2A. The elevated MT2A, BAX, EGF and JUN expression was associated with the influence of tumour cells on the rearrangement of healthy
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Tumor Biology
ISSN
1010-4283
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
12
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
9929-9939
UT code for WoS article
000367329300092
EID of the result in the Scopus database
2-s2.0-84951325946