Predictors and outcomes of moderately severe acute pancreatitis - Evidence to reclassify

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00066207" target="_blank" >RIV/00159816:_____/16:00066207 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00092631

Result on the web

<a href="http://dx.doi.org/10.1016/j.pan.2016.08.001" target="_blank" >http://dx.doi.org/10.1016/j.pan.2016.08.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pan.2016.08.001" target="_blank" >10.1016/j.pan.2016.08.001</a>

Result language

angličtina

Original language name

Predictors and outcomes of moderately severe acute pancreatitis - Evidence to reclassify

Original language description

Background/objectives After the creation of the moderately severe acute pancreatitis (MSAP) category in the Revised Atlanta Classification in 2012, predictors to identify these patients early have not been identified. The MSAP category includes patients with (peri)pancreatic necrosis, fluid collections, and transient organ failure in the same category. However, these outcomes have not been studied to determine whether they result in similar outcomes to merit inclusion in the same severity. Methods Retrospective, review of 514 consecutive, direct admissions for acute pancreatitis from 2010 to 2013. Multivariate logistic regression identified predictors of MSAP. Results Persistent SIRS was the best prognostic marker of MSAP with AUC 0.72. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for persistent SIRS to predict MSAP are: 55%, 88%, 40%, 93%, and 84%. Patients with necrosis had significantly longer length of stay (LOS) (p = 0.0001) and higher rates of ICU admission (p = 0.02) compared with patients with transient organ failure. Compared to those with acute fluid collections, patients with necrosis had longer LOS (p < 0.0001), higher rates of ICU admission (p = 0.0005), required more interventions (p = 0.001), and demonstrated higher mortality (0.003). Discussion Moderately severe pancreatitis can be distinguished from mild pancreatitis on the basis of persistent SIRS but cannot be accurately distinguished from severe pancreatitis in the first 48 h (Peri)pancreatic necrosis demonstrates significantly more morbidity compared to the other components of MSAP of fluid collections and transient organ failure.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pancreatology

ISSN

1424-3903

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

6

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

940-945

UT code for WoS article

000388544000002

EID of the result in the Scopus database

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