Strategies to optimize siRNA delivery to hepatocellular carcinoma cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00066628" target="_blank" >RIV/00159816:_____/17:00066628 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/17425247.2017.1292247" target="_blank" >http://dx.doi.org/10.1080/17425247.2017.1292247</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/17425247.2017.1292247" target="_blank" >10.1080/17425247.2017.1292247</a>

Result language
angličtina
Original language name
Strategies to optimize siRNA delivery to hepatocellular carcinoma cells
Original language description
Introduction: hepatocellular carcinoma (hcc) is the predominant form of primary liver cancer and the second leading cause of cancer-associated mortality worldwide. available therapies for hcc have limited efficacy due to often late diagnosis and the general resistance of hcc to anti-cancer agents; therefore, the development of novel therapeutics is urgently required. small-interfering rna (sirna) molecules are short, double-stranded rnas that specifically recognize and bind the mrna of a target gene to inhibit gene expression. despite the great therapeutic potential of sirnas towards many human tumors including hcc, their use is limited by suboptimal delivery.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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