miRNA and lncRNA as Potential Tissue Biomarkers in Hepatocellular Carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F24%3A10470069" target="_blank" >RIV/00216208:11140/24:10470069 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/24:10470069
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=p086S4-OaP" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=p086S4-OaP</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ncrna.2023.10.010" target="_blank" >10.1016/j.ncrna.2023.10.010</a>
Alternative languages
Result language
angličtina
Original language name
miRNA and lncRNA as Potential Tissue Biomarkers in Hepatocellular Carcinoma
Original language description
Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene expression and through inhibitory competitive binding of miRNA influence cellular processes including carcinogenesis. Extensive evidence proved that certain miRNA's are specifically expressed in neoplastic tissues of HCC patients and are confirmed as important factors that can participate in the regulation of key signalling pathways in cancer cells. As such, miRNAs have a great potential in the clinical diagnosis and treatment of HCC and can improve the limitations of standard diagnosis and treatment. Long non-coding RNAs (lncRNAs) have a critical role in the development and progression of HCC. HCC-related lncRNAs have been demonstrated to exhibit abnormal expression and contribute to transformation process (such as proliferation, apoptosis, accelerated vascular formation, and gain of invasive potential) through their interaction with DNA, RNA, or proteins. LncRNAs can bind mRNAs to release their target mRNA and enable its translation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Non-coding RNA Research
ISSN
2468-2160
e-ISSN
2468-0540
Volume of the periodical
9
Issue of the periodical within the volume
1
Country of publishing house
IN - INDIA
Number of pages
9
Pages from-to
24-32
UT code for WoS article
001124588400001
EID of the result in the Scopus database
2-s2.0-85177860108