Intravenous thrombolysis for ischemic stroke in the golden hour: propensity-matched analysis from the SITS-EAST registry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00066851" target="_blank" >RIV/00159816:_____/17:00066851 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00100262

Result on the web

<a href="http://dx.doi.org/10.1007/s00415-017-8461-8" target="_blank" >http://dx.doi.org/10.1007/s00415-017-8461-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00415-017-8461-8" target="_blank" >10.1007/s00415-017-8461-8</a>

Result language

angličtina

Original language name

Intravenous thrombolysis for ischemic stroke in the golden hour: propensity-matched analysis from the SITS-EAST registry

Original language description

As there are scarce data regarding the outcomes of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) within 60 min from symptom onset (&quot;golden hour&quot;), we sought to compare outcomes between AIS patients treated within [GH(+)] and outside [GH(MINUS SIGN )] the &quot;golden hour&quot; by analyzing propensity score matched data from the SITS-EAST registry. Clinical recovery (CR) at 2 and 24 h was defined as a reduction of GREATER-THAN OR EQUAL TO10 points on NIHSS-score or a total NIHSS-score of LESS-THAN OR EQUAL TO3 at 2 and 24 h, respectively. A relative reduction in NIHSS-score of GREATER-THAN OR EQUAL TO40% at 2 h was considered predictive of complete recanalization (CREC). Symptomatic intracranial hemorrhage (sICH) was defined using SITS-MOST criteria. Favorable functional outcome (FFO) was defined as a mRS-score of 0-1 at 3 months. Out of 19,077 IVT-treated AIS patients, 71 GH(+) patients were matched to 6882 GH(MINUS SIGN ) patients, with no differences in baseline characteristics (p &gt; 0.1). GH(+) had higher rates of CR at 2 (31.0 vs. 12.4%; p &lt; 0.001) and 24 h (41 vs. 27%; p = 0.010), CREC at 2 h (39 vs. 21%; p &lt; 0.001) and FFO (46.5 vs. 34.0%; p = 0.028) at 3 months. The rates of sICH and 3-month mortality did not differ (p &gt; 0.2) between the two groups. GH(+) was associated with 2-h CR (OR: 5.34; 95% CI 2.53-11.03) and CREC (OR: 2.38; 95% CI 1.38-4.09), 24-h CR (OR: 1.88; 95% CI 1.08-3.26) and 3-month FFO (OR: 2.02; 95% CI 1.15-3.54) in multivariable logistic regression models adjusting for potential confounders. In conclusion, AIS treated with IVT within the GH seems to have substantially higher odds of early neurological recovery, CREC, 3-month FFO and functional improvement.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurology

ISSN

0340-5354

e-ISSN

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Volume of the periodical

264

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

912-920

UT code for WoS article

000400617200011

EID of the result in the Scopus database

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