YAP regulates cell mechanics by controlling focal adhesion assembly
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00066928" target="_blank" >RIV/00159816:_____/17:00066928 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00096704 RIV/61989592:15110/17:73584997
Result on the web
<a href="http://dx.doi.org/10.1038/ncomms15321" target="_blank" >http://dx.doi.org/10.1038/ncomms15321</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ncomms15321" target="_blank" >10.1038/ncomms15321</a>
Alternative languages
Result language
angličtina
Original language name
YAP regulates cell mechanics by controlling focal adhesion assembly
Original language description
Hippo effectors YAP/TAZ act as on-off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control of focal adhesions (FAs). Here we unveil the molecular mechanism by which cell spreading and RhoA GTPase activity control FA formation through YAP to stabilize the anchorage of the actin cytoskeleton to the cell membrane. This mechanism requires YAP co-transcriptional function and involves the activation of genes encoding for integrins and FA docking proteins. Tuning YAP transcriptional activity leads to the modification of cell mechanics, force development and adhesion strength, and determines cell shape, migration and differentiation. These results provide new insights into the mechanism of YAP mechanosensing activity and qualify this Hippo effector as the key determinant of cell mechanics in response to ECM cues.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
MAY
Country of publishing house
GB - UNITED KINGDOM
Number of pages
22
Pages from-to
15321
UT code for WoS article
000401279200001
EID of the result in the Scopus database
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