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YAP regulates cell mechanics by controlling focal adhesion assembly

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00066928" target="_blank" >RIV/00159816:_____/17:00066928 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/17:00096704 RIV/61989592:15110/17:73584997

  • Result on the web

    <a href="http://dx.doi.org/10.1038/ncomms15321" target="_blank" >http://dx.doi.org/10.1038/ncomms15321</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/ncomms15321" target="_blank" >10.1038/ncomms15321</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    YAP regulates cell mechanics by controlling focal adhesion assembly

  • Original language description

    Hippo effectors YAP/TAZ act as on-off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control of focal adhesions (FAs). Here we unveil the molecular mechanism by which cell spreading and RhoA GTPase activity control FA formation through YAP to stabilize the anchorage of the actin cytoskeleton to the cell membrane. This mechanism requires YAP co-transcriptional function and involves the activation of genes encoding for integrins and FA docking proteins. Tuning YAP transcriptional activity leads to the modification of cell mechanics, force development and adhesion strength, and determines cell shape, migration and differentiation. These results provide new insights into the mechanism of YAP mechanosensing activity and qualify this Hippo effector as the key determinant of cell mechanics in response to ECM cues.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nature Communications

  • ISSN

    2041-1723

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    MAY

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    22

  • Pages from-to

    15321

  • UT code for WoS article

    000401279200001

  • EID of the result in the Scopus database