Nocturnal Dynamics of Sleep-Wake Transitions in Patients With Narcolepsy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067032" target="_blank" >RIV/00159816:_____/17:00067032 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1093/sleep/zsw050" target="_blank" >http://dx.doi.org/10.1093/sleep/zsw050</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/sleep/zsw050" target="_blank" >10.1093/sleep/zsw050</a>

Result language

angličtina

Original language name

Nocturnal Dynamics of Sleep-Wake Transitions in Patients With Narcolepsy

Original language description

Introduction: We investigate how characteristics of sleep-wake dynamics in humans are modified by narcolepsy, a clinical condition that is supposed to destabilize sleep-wake regulation. Subjects with and without cataplexy are considered separately. Differences in sleep scoring habits as a possible confounder have been examined. Aims and Methods: Four groups of subjects are considered: narcolepsy patients from China with (n = 88) and without (n = 15) cataplexy, healthy controls from China (n = 110) and from Europe (n = 187, 2 nights each). After sleep-stage scoring and calculation of sleep characteristic parameters, the distributions of wake-episode durations and sleep-episode durations are determined for each group and fitted by power laws (exponent a) and by exponentials (decay time tau). Results: We find that wake duration distributions are consistent with power laws for healthy subjects (China: alpha = 0.88, Europe: alpha = 1.02). Wake durations in all groups of narcolepsy patients, however, follow the exponential law (tau = 6.2-8.1 min). All sleep duration distributions are best fitted by exponentials on long time scales (tau = 34-82 min). Conclusions: We conclude that narcolepsy mainly alters the control of wake-episode durations but not sleep-episode durations, irrespective of cataplexy. Observed distributions of shortest wake and sleep durations suggest that differences in scoring habits regarding the scoring of short-term sleep stages may notably influence the fitting parameters but do not affect the main conclusion.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Sleep

ISSN

1550-9109

e-ISSN

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Volume of the periodical

40

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

"zsw050"

UT code for WoS article

000394129900013

EID of the result in the Scopus database

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