Increased microcirculatory heterogeneity in patients with obstructive sleep apnea

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067147" target="_blank" >RIV/00159816:_____/17:00067147 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00097612 RIV/65269705:_____/17:00067147

Result on the web

<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184291" target="_blank" >http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184291</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0184291" target="_blank" >10.1371/journal.pone.0184291</a>

Result language

angličtina

Original language name

Increased microcirculatory heterogeneity in patients with obstructive sleep apnea

Original language description

Obstructive sleep apnea (OSA) is the most common form of sleep disordered breathing and has been associated with major cardiovascular comorbidities. We hypothesized that the microcirculation is impaired in patients with OSA and that the magnitude of impairment correlates to OSA severity. Methods Subjects were consecutive patients scheduled for routine diagnostic polysomnography (PSG). OSA was defined by paradoxical rib cage movements together with abdominal excursions and by the apnea-hypopnea index (AHI) (events/hour; no apnea AHI&lt;5; mild apnea 5LESS-THAN OR EQUAL TOAHI&lt;15; moderate apnea 15LESS-THAN OR EQUAL TOAHI&lt;30; severe apnea AHI GREATER-THAN OR EQUAL TO30). Sidestream darkfield imaging was used to assess the sublingual microcirculation. Recordings of sublingual microcirculation (5 random sites) were performed before and after overnight PSG. Data are summarized as mean (+-SD); p values &lt;0.05 were considered statistically significant. Results Thirty-three consecutive patients were included. OSA was diagnosed in 16 subjects (4 moderate, 12 severe). There was no significant difference in microcirculation between subjects with moderate OSA and without OSA. However, compared to subjects without OSA, subjects with severe OSA (AHIGREATER-THAN OR EQUAL TO30) showed a significant decrease of microvascular flow index (-0.07+-0.17 vs. 0.08+-0.14; p = 0.02) and increase of microvascular flow index heterogeneity (0.06+-0.15 vs. -0.06+-0.11; p = 0.02) overnight. Multiple regression analysis (adjusted for age and gender) showed both decrease of flow and increase of flow heterogeneity associated with AHI (b = -0.41; F = 1.8; p = 0.04 and b = 0.43; F = 1.9; p = 0.03, respectively). Conclusion Acute overnight microcirculatory changes are observed in subjects with severe OSA characterized by decreased flow and increased flow heterogeneity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

"e0184291"

UT code for WoS article

000408816900046

EID of the result in the Scopus database

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