Severity of individual obstruction events increases with age in patients with obstructive sleep apnea

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00068405" target="_blank" >RIV/00159816:_____/17:00068405 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.sleep.2017.06.004" target="_blank" >http://dx.doi.org/10.1016/j.sleep.2017.06.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sleep.2017.06.004" target="_blank" >10.1016/j.sleep.2017.06.004</a>

Result language

angličtina

Original language name

Severity of individual obstruction events increases with age in patients with obstructive sleep apnea

Original language description

Background: Age is a risk factor of obstructive sleep apnea (OSA). It has been shown that OSA progresses over time, although conflicting results have been reported. However, the effect of age on the severity of OSA and individual obstruction events has not been investigated within different OSA severity categories by taking the most prominent confounding factors (i.e., body mass index, gender, smoking, daytime sleepiness, snoring, hypertension, heart failure, and proportion of supine sleep) into account. Methods: Polygraphic data of 1090 patients with apneaehypopnea index (AHI) &gt;= 5 were retrospectively reanalyzed. The effect of age on the severity of OSA and obstruction events was investigated in general, within different OSA severity categories, and in different age groups (age &lt; 40, 40 &lt;= age &lt; 50, 50 &lt;= age &lt; 60, and age &lt;= 60 years). Results: In the whole population, AHI and durations of apneas, hypopneas, and desaturations increased with increasing age (B &gt;= 0.108, p &lt;= 0.010). In more detailed analysis, AHI increased with age only in the moderate OSA category (B = 0.075, p = 0.022), although durations of apneas increased in mild and severe OSA categories (B &gt;= 0.076, p &lt;= 0.038). Furthermore, durations of hypopneas increased with age in mild and moderate OSA categories (B &gt;= 0.105, p &lt;= 0.038), and durations of desaturations (B &gt;= 0.120, p &lt;= 0.013) in all OSA severity categories. AHI was not statistically significantly different between the age groups, although durations of obstruction events tended to increase towards older age groups. Conclusion: As obstruction event severity was more strongly dependent on the age than it was dependent on AHI, considering the severity of obstruction events could be beneficial while estimating the long-term effects of the treatments and prognosticating the disease progression.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Sleep medicine

ISSN

1389-9457

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

September

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

32-37

UT code for WoS article

000410792900007

EID of the result in the Scopus database

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