Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimers Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067153" target="_blank" >RIV/00159816:_____/17:00067153 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/17:10373766 RIV/00064203:_____/17:10373766

Result on the web

<a href="http://dx.doi.org/10.3389/fneur.2017.00399" target="_blank" >http://dx.doi.org/10.3389/fneur.2017.00399</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fneur.2017.00399" target="_blank" >10.3389/fneur.2017.00399</a>

Result language

angličtina

Original language name

Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimers Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach

Original language description

Deep gray matter structures are associated with memory and other important functions that are impaired in Alzheimer&apos;s disease (AD) and mild cognitive impairment (MCI). However, systematic characterization of the subregional atrophy and deformations in these structures in AD and MCI still need more investigations. In this article, we combined complex volumetry- and vertex-based analysis to investigate the pattern of subregional structural alterations in deep gray matter structures and its association with global clinical scores in AD (n = 30) and MCI patients (n = 30), compared to normal controls (NCs, n = 30). Among all seven pairs of structures, the bilateral hippocampi and nucleus accumbens showed significant atrophy in AD compared with NCs (p &lt; 0.05). But only the subregional atrophy in the dorsal-medial part of the left hippocampus, the ventral part of right hippocampus, and the left nucleus accumbens, the posterior part of the right nucleus accumbens correlated with the worse clinical scores of MMSE and MOCA (p &lt; 0.05). Furthermore, the medial-ventral part of right thalamus significantly shrank and correlated with clinical scores without decreasing in its whole volume (p &gt; 0.05). In conclusion, the atrophy of these four subregions in bilateral hippocampi and nucleus accumbens was associated with cognitive impairment of patients, which might be potential target regions of treatment in AD. The surface analysis could provide additional information to volume comparison in finding the early pathological progress in deep gray matter structures.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Neurology

ISSN

1664-2295

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

AUG

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

399

UT code for WoS article

000407592700001

EID of the result in the Scopus database

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