Mitochondrial dynamics in Parkinson's disease: a role for alpha-synuclein?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067442" target="_blank" >RIV/00159816:_____/17:00067442 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1242/dmm.026294" target="_blank" >http://dx.doi.org/10.1242/dmm.026294</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1242/dmm.026294" target="_blank" >10.1242/dmm.026294</a>

Result language

angličtina

Original language name

Mitochondrial dynamics in Parkinson's disease: a role for alpha-synuclein?

Original language description

The distinctive pathological hallmarks of Parkinson&apos;s disease are the progressive death of dopaminergic neurons and the intracellular accumulation of Lewy bodies enriched in a-synuclein protein. Several lines of evidence from the study of sporadic, familial and pharmacologically induced forms of human Parkinson&apos;s disease also suggest that mitochondrial dysfunction plays an important role in disease progression. Although many functions have been proposed for a-synuclein, emerging data from human and animal models of Parkinson&apos;s disease highlight a role for a-synuclein in the control of neuronal mitochondrial dynamics. Here, we review the a-synuclein structural, biophysical and biochemical properties that influence relevant mitochondrial dynamic processes such as fusion-fission, transport and clearance. Drawing on current evidence, we propose that a-synuclein contributes to the mitochondrial defects that are associated with the pathology of this common and progressive neurodegenerative disease.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/EF15_003%2F0000492" target="_blank" >EF15_003/0000492: Unveiling the molecular determinants of agingto design new therapeutics</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Disease Models &amp; Mechanisms

ISSN

1754-8403

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

1075-1087

UT code for WoS article

000409446400003

EID of the result in the Scopus database

—