Intracellular and Intercellular Mitochondrial Dynamics in Parkinson’s Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F19%3A00521553" target="_blank" >RIV/86652036:_____/19:00521553 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fnins.2019.00930/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnins.2019.00930/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnins.2019.00930" target="_blank" >10.3389/fnins.2019.00930</a>

Result language

angličtina

Original language name

Intracellular and Intercellular Mitochondrial Dynamics in Parkinson’s Disease

Original language description

The appearance of alpha-synuclein-positive inclusion bodies (Lewy bodies) and the loss of catecholaminergic neurons are the primary pathological hallmarks of Parkinson’s disease (PD). However, the dysfunction of mitochondria has long been recognized as a key component in the progression of the disease. Dysfunctional mitochondria can in turn lead to dysregulation of calcium homeostasis and, especially in dopaminergic neurons, raised mean intracellular calcium concentration. As calcium binding to alpha-synuclein is one of the important triggers of alpha-synuclein aggregation, mitochondrial dysfunction will promote inclusion body formation and disease progression. Increased reactive oxygen species (ROS) resulting from inefficiencies in the electron transport chain also contribute to the formation of alpha-synuclein aggregates and neuronal loss. Recent studies have also highlighted defects in mitochondrial clearance that lead to the accumulation of depolarized mitochondria. Transaxonal and intracytoplasmic translocation of mitochondria along the microtubule cytoskeleton may also be affected in diseased neurons. Furthermore, nanotube-mediated intercellular transfer of mitochondria has recently been reported between different cell types and may have relevance to the spread of PD pathology between adjacent brain regions. In the current review, the contributions of both intracellular and intercellular mitochondrial dynamics to the etiology of PD will be discussed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FRONT NEUROSCI-SWITZ

ISSN

1662-4548

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

SEP 18 2019

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

930

UT code for WoS article

000486406800001

EID of the result in the Scopus database

2-s2.0-85072898645