Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067617" target="_blank" >RIV/00159816:_____/17:00067617 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00098708 RIV/00209805:_____/17:00077871

Result on the web

<a href="http://dx.doi.org/10.1016/j.radonc.2016.12.013" target="_blank" >http://dx.doi.org/10.1016/j.radonc.2016.12.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.radonc.2016.12.013" target="_blank" >10.1016/j.radonc.2016.12.013</a>

Result language

angličtina

Original language name

Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study

Original language description

Background and purpose: The aim of this prospective study is to evaluate post -whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate those changes to neurocognitive function. Material and methods: Thirty-five patients with brain metastases underwent baseline single slice multivoxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20). Eighteen patients completed follow-up evaluation four months after standard WBRT (2 laterolateral fields, 10 x 3.0 Gy, 6 MV photons) and were included in this analysis. MRS and cognitive examinations were repeated and compared to baseline measurements. Results: Statistically significant decreases in h-tNAA were observed in the right (8.52-7.42 mM; -12.9%, 95%Cl: -7.6 to -16.4%) as well as in the left hippocampus (8.64-7.60 mM; -12%, 95%Cl: -7.9 to -16.2%). Statistically significant decline was observed in all AVLT and BVMT-R subtests with exception of AVLT_Recognition. Quality of life declined after WBRT (mean Delta-14.1 +/- 20.3 points in transformed 0100 point scale; p = 0.018) with no correlation to changes in hippocampal metabolite concentrations. Moderate positive correlation was observed between left h-tNAA concentration decrease and AVLT_TR decline (r = +0.32; p = 0.24) as well as with AVLT_DR (r = +0.33; p = 0.22) decline. Changes in right htNAA/Cr negatively correlated with AVLT_DR (r = -0.48; p = 0.061).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiotherapy and oncology

ISSN

0167-8140

e-ISSN

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Volume of the periodical

112

Issue of the periodical within the volume

3

Country of publishing house

IE - IRELAND

Number of pages

7

Pages from-to

373-379

UT code for WoS article

000397691500008

EID of the result in the Scopus database

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