Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00068163" target="_blank" >RIV/00159816:_____/17:00068163 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00095707
Result on the web
<a href="http://dx.doi.org/10.1002/mds.26956" target="_blank" >http://dx.doi.org/10.1002/mds.26956</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mds.26956" target="_blank" >10.1002/mds.26956</a>

Result language
angličtina
Original language name
Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition
Original language description
Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease. Objectives: The objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared. Methods: Seed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between-group differences and clinical outcomes was assessed. Results: Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease. Conclusions: Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. (C) 2017 International Parkinson and Movement Disorder Society
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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