Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00080538" target="_blank" >RIV/00159816:_____/24:00080538 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00135655
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1353802024000439" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1353802024000439</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.parkreldis.2024.106031" target="_blank" >10.1016/j.parkreldis.2024.106031</a>
Alternative languages
Result language
angličtina
Original language name
Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies
Original language description
Background: Functional connectivity changes in clinically overt neurodegenerative diseases such as dementia with Lewy bodies have been described, but studies on connectivity changes in the pre -dementia phase are scarce. Objectives: We concentrated on evaluating striato-cortical functional connectivity differences between patients with Mild Cognitive Impairment with Lewy bodies and healthy controls and on assessing the relation to cognition. Methods: Altogether, we enrolled 77 participants (47 patients, of which 35 met all the inclusion criteria for the final analysis, and 30 age- and gender -matched healthy controls, of which 28 met all the inclusion criteria for the final analysis) to study the seed -based connectivity of the dorsal, middle, and ventral striatum. We assessed correlations between functional connectivity in the regions of between -group differences and neuropsychological scores of interest (visuospatial and executive domains z -scores). Results: Subjects with Mild Cognitive Impairment with Lewy Bodies, as compared to healthy controls, showed increased connectivity from the dorsal part of the striatum particularly to the bilateral anterior part of the temporal cortex with an association with executive functions. Conclusions: We were able to capture early abnormal connectivity within cholinergic and noradrenergic pathways that correlated with cognitive functions known to be linked to cholinergic/noradrenergic deficits. The knowledge of specific alterations may improve our understanding of early neural changes in pre -dementia stages and enhance research of disease modifying therapy.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parkinsonism & Related Disorders
ISSN
1353-8020
e-ISSN
1873-5126
Volume of the periodical
121
Issue of the periodical within the volume
2024
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
106031
UT code for WoS article
001188128400001
EID of the result in the Scopus database
—