Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00068393" target="_blank" >RIV/00159816:_____/17:00068393 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s11011-017-9961-z" target="_blank" >http://dx.doi.org/10.1007/s11011-017-9961-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11011-017-9961-z" target="_blank" >10.1007/s11011-017-9961-z</a>

Result language

angličtina

Original language name

Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults

Original language description

Excessive adipose tissue, particularly with a central distribution, consists of visceral fat, which is metabolically active and could impinge upon central nervous system functioning. The aim of the current study was to examine levels of visceral adiposity in relation to key cerebral metabolite ratios localized in the occipitoparietal grey matter. Seventy-three adults, aged between 40 and 60 years, underwent structural magnetic resonance imaging and single voxel H-1 Magnetic Resonance Spectroscopy (H-1 MRS). Visceral fat was assessed using Dual Energy X Ray Absorptiometry (DXA). Individuals with higher visceral fat mass and volume had significantly lower ratios of N-acetyl-aspartate to total creatine (phosphocreatine + creatine, PCr + Cr) (NAA/PCr + Cr) (beta = -0.29, p = 0.03, beta = -0.28, p = 0.04). They also had significantly higher ratios of myo-inositol to total creatine (mI/PCr + Cr ) (beta = 0.36, p = 0.01, beta = 0.36, p = 0.01). Visceral fat mass and volume were not significantly related to ratios of glutamate to total creatine (Glu/PCr + Cr). While future studies are necessary, these results indicate central adiposity is associated with metabolic changes that could impinge upon the central nervous system in middle age.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

METABOLIC BRAIN DISEASE

ISSN

0885-7490

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

727-733

UT code for WoS article

000400767700009

EID of the result in the Scopus database

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