Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068889" target="_blank" >RIV/00159816:_____/18:00068889 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00104102

Result on the web

<a href="http://dx.doi.org/10.1055/s-0037-1607396" target="_blank" >http://dx.doi.org/10.1055/s-0037-1607396</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0037-1607396" target="_blank" >10.1055/s-0037-1607396</a>

Result language

angličtina

Original language name

Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation

Original language description

Introduction We analyzed the results of vagus nerve stimulation (VNS) on older patients and patients with long-lasting epilepsy and included severely intellectually disabled patients. Patients and Methods A total of 103 adults with VNS implanted from 2005 to 2014 were studied. The responder rates, that is, the percentage of VNS patients who responded to VNS, classified as seizure reduction50% (50R) and seizure reduction90% (90R), were compared in defined age groups (&lt; 40 and40 years, and&lt;50 and50 years) and epilepsy duration groups (&lt; 20 and20 years,&lt;30 and30 years, and&lt;40 and40 years) at the 1-year follow-up visit and the last follow-up visit (at least 2 years after surgery). The age distributions and responder rates were also studied in patients with an intellectual disability. Results The analysis did not confirm a significantly lower 50R or 90R rate in patients40,50, or60 years when compared with their younger counterparts, but the 50R rate increase during follow-up care was the lowest in patients50 and60 years. The highest percentage of patients with an intellectual disability in the group&lt;40 years of age did not adversely affect the 50R rate. Longer epilepsy duration was not confirmed as a negative predictor of VNS outcome. There was a significantly higher 50R rate in patients with epilepsy duration20 years (at the last follow-up visit) and a higher 90R rate in patients with epilepsy duration30 years (at the 1-year follow-up visit). The increase in the 50R rate during follow-up care was lower in patients with epilepsy durations30 and40 years. Conclusions The study did not find worse VNS outcomes, as defined by the 50R or 90R rate, in older adult patients or in patients with a longer epilepsy duration. The increasing stimulation effect over time is less marked in older patients and in patients with longer epilepsy duration.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurological Surgery Part A-Central European Neurosurgery

ISSN

2193-6315

e-ISSN

—

Volume of the periodical

79

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

152-158

UT code for WoS article

000426299500008

EID of the result in the Scopus database

2-s2.0-85035358015