Disruption of Multiple Distinctive Neural Networks Associated With Impulse Control Disorder in Parkinson's Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00069078" target="_blank" >RIV/00159816:_____/18:00069078 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/18:00069078 RIV/00216224:14110/18:00106960

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fnhum.2018.00462/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnhum.2018.00462/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnhum.2018.00462" target="_blank" >10.3389/fnhum.2018.00462</a>

Result language

angličtina

Original language name

Disruption of Multiple Distinctive Neural Networks Associated With Impulse Control Disorder in Parkinson's Disease

Original language description

The phenomenon of impulsivity in Parkinson&apos;s disease appears as an arduous side effect of dopaminergic therapy with potentially detrimental consequences for the life of the patients. Although conceptualized as a result of non-physiologic chronic dopaminergic stimulation, recent advances speculate on combined disruption of other networks as well. In the search for neuroanatomical correlates of this multifaceted disturbance, this study employs two distinct, well-defined tasks of close association tomotor inhibition and decision-making impulsivity, Go/ No Go and Delay discounting. The fMRI and functional connectivity analysis in 21 Parkinson&apos;s disease patients, including 8 patients suffering from severe impulse control disorder, and 28 healthy controls, revealed in impulsive Parkinson&apos;s disease patients not only decreased fMRI activation in the dorsolateral prefrontal cortex and bilateral striatum, but also vast functional connectivity changes of both caudate nuclei as decreased connectivity to the superior parietal cortex and increased connectivity to the insular area, clearly beyond the commonly stated areas, which indicates that orbitofronto-striatal and mesolimbic functional disruptions are not the sole mechanisms underlying impulse control disorder in Parkinson&apos;s disease. Ergo, our results present a refinement and synthesis of gradually developing ideas about the nature of impulsive control disorder in Parkinson&apos;s disease-an umbrella term encompassing various behavioral deviations related to distinct neuronal networks and presumably neurotransmitter systems, which greatly exceed the previously envisioned dopaminergic pathways as the only culprit.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NV15-30062A" target="_blank" >NV15-30062A: Impulsivity phenotypes and their clinical impact in neuropsychiatric disorders</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Human Neuroscience

ISSN

1662-5161

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

NOV 21

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

462

UT code for WoS article

000450959000001

EID of the result in the Scopus database

2-s2.0-85058997274