Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00069168" target="_blank" >RIV/00159816:_____/18:00069168 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/18:00105857
Result on the web
<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208144" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208144</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0208144" target="_blank" >10.1371/journal.pone.0208144</a>
Alternative languages
Result language
angličtina
Original language name
Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study
Original language description
Most patients with chronic lower back pain (CLBP) exhibit degenerative disc disease. Disc specimens obtained during initial therapeutic discectomies are often infected/colonized with Propionibacterium acnes, a Gram-positive commensal of the human skin. Although pain associated with infection is typically ascribed to the body's inflammatory response, the Gram-positive bacterium Staphylococcus aureus was recently observed to directly activate nociceptors by secreting pore-forming alpha-hemolysins that disrupt neuronal cell membranes. The hemolytic activity of P. acnes in cultured disc specimens obtained during routine therapeutic discectomies was assessed through incubation on sheep-blood agar. The beta-hemolysis pattern displayed by P. acnes on sheep-blood agar was variable and phylogroup-dependent. Their molecular phylogroups were correlated with their hemolytic patterns. Our findings raise the possibility that pore-forming proteins contribute to the pathogenesis and/or symptomology of chronic P. acnes disc infections and CLBP, at least in a subset of cases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
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UT code for WoS article
000451763800100
EID of the result in the Scopus database
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