Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070949" target="_blank" >RIV/00159816:_____/19:00070949 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/19:00108499 RIV/65269705:_____/19:00070949
Result on the web
<a href="https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0218269&type=printable" target="_blank" >https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0218269&type=printable</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0218269" target="_blank" >10.1371/journal.pone.0218269</a>
Alternative languages
Result language
angličtina
Original language name
Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers
Original language description
Although the administration of retinoids represents an important part of treatment for children suffering from high-risk neuroblastomas, approximately 50% of these patients do not respond to this therapy or develop resistance to retinoids during treatment. Our study focused on the comparative analysis of the expression of five genes and corresponding proteins (DDX39A, HMGA1, HMGA2, HOXC9 and PBX1) that have recently been discussed as possible predictive biomarkers of clinical response to retinoid differentiation therapy. Expression of these five candidate biomarkers was evaluated at both the mRNA and protein level in the same subset of 8 neuroblastoma cell lines after treatment with natural or synthetic retinoids. We found that the cell lines that were HMGA2-positive and/or HOXC9-negative have a reduced sensitivity to retinoids. Furthermore, the experiments revealed that the retinoid-sensitive cell lines showed a uniform pattern of change after treatment with both natural and sensitive retinoids: increased DDX39A and decreased PBX1 protein levels. Our results showed that in NBL cells, these putative protein biomarkers are associated with sensitivity or resistance to retinoids, and their endogenous or induced expression can distinguish between these two phenotypes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30500 - Other medical sciences
Result continuities
Project
<a href="/en/project/NV15-34621A" target="_blank" >NV15-34621A: Candidate biomarkers of resistance to retinoids in children with high-risk neuroblastoma</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
"e0218269"
UT code for WoS article
000471234500064
EID of the result in the Scopus database
2-s2.0-85067190738