Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068540" target="_blank" >RIV/00159816:_____/18:00068540 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/18:00068540 RIV/00216224:14310/18:00106917

Result on the web

<a href="http://www.mdpi.com/1422-0067/19/1/132/htm" target="_blank" >http://www.mdpi.com/1422-0067/19/1/132/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms19010132" target="_blank" >10.3390/ijms19010132</a>

Result language

angličtina

Original language name

Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids

Original language description

Retinoids represent a popular group of differentiation inducers that are successfully used in oncology for treatment of acute promyelocytic leukemia in adults and of neuroblastoma in children. The therapeutic potential of retinoids is based on their key role in the regulation of cell differentiation, growth, and apoptosis, which provides a basis for their use both in cancer therapy and chemoprevention. Nevertheless, patients treated with retinoids often exhibit or develop resistance to this therapy. Although resistance to retinoids is commonly categorized as either acquired or intrinsic, resistance as a single phenotypic feature is usually based on the same mechanisms that are closely related or combined in both of these types. In this review, we summarize the most common changes in retinoid metabolism and action that may affect the sensitivity of a tumor cell to treatment with retinoids. The availability of retinoids can be regulated by alterations in retinol metabolism or in retinoid intracellular transport, by degradation of retinoids or by their efflux from the cell. Retinoid effects on gene expression can be regulated via retinoid receptors or via other molecules in the transcriptional complex. Finally, the role of small-molecular-weight inhibitors of altered cell signaling pathways in overcoming the resistance to retinoids is also suggested.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

132

UT code for WoS article

000424407200129

EID of the result in the Scopus database

2-s2.0-85041829608