Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00106917" target="_blank" >RIV/00216224:14310/18:00106917 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/18:00068540 RIV/65269705:_____/18:00068540
Result on the web
<a href="http://www.mdpi.com/1422-0067/19/1/132" target="_blank" >http://www.mdpi.com/1422-0067/19/1/132</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms19010132" target="_blank" >10.3390/ijms19010132</a>

Result language
angličtina
Original language name
Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids
Original language description
In this review, we summarize the most common changes in retinoid metabolism and action that may affect the sensitivity of a tumor cell to treatment with retinoids. The availability of retinoids can be regulated by alterations in retinol metabolism or in retinoid intracellular transport, by degradation of retinoids or by their efflux from the cell. Retinoid effects on gene expression can be regulated via retinoid receptors or via other molecules in the transcriptional complex. Finally, the role of small-molecular-weight inhibitors of altered cell signaling pathways in overcoming the resistance to retinoids is also suggested.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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