MicroRNA regulation of cancer metabolism: role in tumour suppression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F14%3A00441822" target="_blank" >RIV/86652036:_____/14:00441822 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.mito.2014.06.004" target="_blank" >http://dx.doi.org/10.1016/j.mito.2014.06.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mito.2014.06.004" target="_blank" >10.1016/j.mito.2014.06.004</a>

Result language

angličtina

Original language name

MicroRNA regulation of cancer metabolism: role in tumour suppression

Original language description

Mitochondria are critical regulators of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders, including cancer. Altered metabolism is a common property of cancer cells that exhibit enhanced capacity to 'ferment' glucose to pyruvate and then lactate, even in the presence of sufficient oxygen to support mitochondrial metabolism. Recently, it was reported that microRNAs (miRNAs) regulate important signalling pathways in mitochondria and many of these miRNAs are deregulated in various cancers. Different regulatory mechanisms can control miRNA expression at the genetic or epigenetic level, thus affecting the biogenetic machinery via recruitment of specific transcription factors. Metabolic reprogramming that cancer cells undergo during tumorigenesis offers a wide range of potential targets to impair tumour progression. MiRNAs participate in controlling cancer cell metabolism by regulating the expression of genes whose protein products either directly r

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mitochondrion

ISSN

1567-7249

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

part a SI

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

29-38

UT code for WoS article

000346624700005

EID of the result in the Scopus database

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