The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F16%3A00465807" target="_blank" >RIV/86652036:_____/16:00465807 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1515/hsz-2016-0130" target="_blank" >http://dx.doi.org/10.1515/hsz-2016-0130</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/hsz-2016-0130" target="_blank" >10.1515/hsz-2016-0130</a>

Result language

angličtina

Original language name

The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria

Original language description

Altered metabolism and resistance to cell death are typical hallmarks of cancer phenotype. Mitochondria are organelles central to cellular metabolism as well as to cell death induction. Hyperactivation of pro-survival and pro-proliferative pathways such as PI3K/AKT leads to cancer initiation, which affects mitochondria. Growing body of evidence indicates that oncogenes such as HER2, EGFR and RAS, as well as the downstream members of the PI3K/AKT signaling pathway, directly regulate mitochondria by translocating to the organelle. Here we discuss evidence of this scenario and consider mechanisms for direct regulation of mitochondrial function. Being in close proximity to mitochondrial bioenergetics machinery as well as to the regulators/executors of programed cell death, oncogenes in mitochondria may be ideally placed to perform this task. This represents a thus far under-explored area, which may be relevant to better understanding of cancer initiation, progression and treatment.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/ED1.1.00%2F02.0109" target="_blank" >ED1.1.00/02.0109: Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biological Chemistry

ISSN

1431-6730

e-ISSN

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Volume of the periodical

397

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

607-615

UT code for WoS article

000377892600004

EID of the result in the Scopus database

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