Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F20%3A00535784" target="_blank" >RIV/86652036:_____/20:00535784 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/21/21/7941" target="_blank" >https://www.mdpi.com/1422-0067/21/21/7941</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms21217941" target="_blank" >10.3390/ijms21217941</a>
Alternative languages
Result language
angličtina
Original language name
Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy
Original language description
Mitochondria are essential cellular organelles, controlling multiple signalling pathways critical for cell survival and cell death. Increasing evidence suggests that mitochondrial metabolism and functions are indispensable in tumorigenesis and cancer progression, rendering mitochondria and mitochondrial functions as plausible targets for anti-cancer therapeutics. In this review, we summarised the major strategies of selective targeting of mitochondria and their functions to combat cancer, including targeting mitochondrial metabolism, the electron transport chain and tricarboxylic acid cycle, mitochondrial redox signalling pathways, and ROS homeostasis. We highlight that delivering anti-cancer drugs into mitochondria exhibits enormous potential for future cancer therapeutic strategies, with a great advantage of potentially overcoming drug resistance. Mitocans, exemplified by mitochondrially targeted vitamin E succinate and tamoxifen (MitoTam), selectively target cancer cell mitochondria and efficiently kill multiple types of cancer cells by disrupting mitochondrial function, with MitoTam currently undergoing a clinical trial.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
21
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
7941
UT code for WoS article
000589143400001
EID of the result in the Scopus database
2-s2.0-85094117459