Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071094" target="_blank" >RIV/00159816:_____/19:00071094 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/19:00108451
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S1043661818316049?token=4AB82BC853F78AE7E93EA091793D0E375F4B72C73B88D48C9F264CC6BCA0B10A09817EB049D3F0A2E650FD6091335195" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1043661818316049?token=4AB82BC853F78AE7E93EA091793D0E375F4B72C73B88D48C9F264CC6BCA0B10A09817EB049D3F0A2E650FD6091335195</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.phrs.2018.11.020" target="_blank" >10.1016/j.phrs.2018.11.020</a>
Alternative languages
Result language
angličtina
Original language name
Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies
Original language description
Mitochondria play vital roles in various cellular processes, ranging from cellular metabolism to signal transduction and cell death regulation. As these properties are critical for cancer growth, the mitochondrion has recently become an attractive target for anti-cancer therapies. In addition, it has come to light that mitochondria are crucially involved in the regulation of stem cell identity, differentiation and fate. A similar role for mitochondria has been also demonstrated in malignant stem-like cells termed cancer stem cells (CSCs), which are implicated in progression and resistance of many tumors. In this review, we summarize different mitochondrial functions reported to promote acquisition and maintenance of CSC phenotype and discuss the rationale for their therapeutic targeting. Particular emphasis is given to therapeutics that act directly through modulation of these mitochondrial functions and have recently emerged as promising anti-CSC drugs in pre-clinical studies. This review highlights the intriguing aspects of mitochondrial biology that may have a crucial role in cancer initiation, progression, and resistance and which might facilitate pharmacological targeting. Indeed, understanding of mitochondrial function in the regulation of CSCs will promote the development of novel CSC-targeted therapeutic strategies, which could significantly improve the long-term survival of cancer patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacological research
ISSN
1043-6618
e-ISSN
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Volume of the periodical
139
Issue of the periodical within the volume
January
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
298-313
UT code for WoS article
000458709000028
EID of the result in the Scopus database
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