MicroRNAs as regulators of mitochondrial function: Role in cancer suppression

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F14%3A00427910" target="_blank" >RIV/86652036:_____/14:00427910 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbagen.2013.09.002" target="_blank" >http://dx.doi.org/10.1016/j.bbagen.2013.09.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbagen.2013.09.002" target="_blank" >10.1016/j.bbagen.2013.09.002</a>

Result language
angličtina
Original language name
MicroRNAs as regulators of mitochondrial function: Role in cancer suppression
Original language description
Background: Mitochondria, essential to the cell homeostasis maintenance, are central to the intrinsic apoptotic pathway and their dysfunction is associated with multiple diseases. Recent research documents that microRNAs (miRNAs) regulate important signalling pathways in mitochondria, and many of these miRNAs are deregulated in various diseases including cancers. Scope of review: In this review, we summarise the role of miRNAs in the regulation of the mitochondrial bioenergetics/function, and discuss the role of miRNAs modulating the various metabolic pathways resulting in tumour suppression and their possible therapeutic applications. Major conclusions: MiRNAs have recently emerged as key regulators of metabolism and can affect mitochondria by modulating mitochondrial proteins coded by nuclear genes. They were also found in mitochondria. Reprogramming of the energy metabolism has been postulated as a major feature of cancer. Modulation of miRNAs levels may provide a new therapeutic ap
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/GAP301%2F10%2F1937" target="_blank" >GAP301/10/1937: Mechanisms of efficient killing of cancer stem cells</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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