The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070970" target="_blank" >RIV/00159816:_____/19:00070970 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00110196
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00432-019-02940-0" target="_blank" >https://link.springer.com/article/10.1007%2Fs00432-019-02940-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00432-019-02940-0" target="_blank" >10.1007/s00432-019-02940-0</a>

Result language
angličtina
Original language name
The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression
Original language description
PurposePhytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis.ResultsThis comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research.ConclusionsSignificant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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