Cortical beta-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071071" target="_blank" >RIV/00159816:_____/19:00071071 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41398-019-0456-z.pdf" target="_blank" >https://www.nature.com/articles/s41398-019-0456-z.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41398-019-0456-x" target="_blank" >10.1038/s41398-019-0456-x</a>
Alternative languages
Result language
angličtina
Original language name
Cortical beta-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging
Original language description
Neuropsychiatric symptoms (NPS) are a risk factor for cognitive impairment and are associated with cortical beta-amyloid (A beta) deposition. We conducted a cross-sectional study derived from the ongoing population-based Mayo Clinic Study of Aging to examine the frequency of NPS among cognitively unimpaired (CU) and mild cognitive impairment (MCI) participants who either have normal (A-) or abnormal (A+) A beta deposition. We also investigated whether combined presence of MCI and amyloid positivity (MCl/A+) is associated with greater odds of having NPS as compared to CU/A- (defined as reference group). Participants were 1627 CU and MCI individuals aged >= 50 years (54% males; median age 73 years). All participants underwent NPS assessment (Neuropsychiatric Inventory Questionnaire (NPI-Q); Beck Depression Inventory II (BDI-II); Beck Anxiety Inventory (BAI)) and C-11-PiB-PET. Participants with an SUVR > 1.42 were classified as A+. We conducted multivariable logistic regression analyses adjusted for age, sex, education, and APOE epsilon 4 genotype status. The sample included 997 CU/A-, 446 CU/A+, 78 MCl/A-, and 106 MCI/A+ persons. For most NPS, the highest frequency of NPS was found in MCI/A+ and the lowest in CU/A-. The odds ratios of having NPS, depression (BDI >= 13), or anxiety (BAI >= 8, >= 10) were consistently highest for MCl/A+ participants. In conclusion, MCI with A beta burden of the brain is associated with an increased risk of having NPS as compared to MCI without A beta burden. This implies that the underlying Alzheimer's disease biology (i.e., cerebral A beta amyloidosis) may drive both cognitive and psychiatric symptoms.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
<a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Translational Psychiatry
ISSN
2158-3188
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
March
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
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UT code for WoS article
000466709300003
EID of the result in the Scopus database
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