Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079779" target="_blank" >RIV/00159816:_____/23:00079779 - isvavai.cz</a>
Result on the web
<a href="https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12557" target="_blank" >https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12557</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/alz.12557" target="_blank" >10.1002/alz.12557</a>

Result language
angličtina
Original language name
Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging
Original language description
Introduction We examined the association between cerebrospinal fluid (CSF)-derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms (NPS) in older non-demented adults. Methods We included 784 persons (699 cognitively unimpaired, 85 with mild cognitive impairment) aged >= 50 years who underwent CSF amyloid beta (A beta 42), hyperphosphorylated tau 181 (p-tau), and total tau (t-tau) as well as NPS assessment using Beck Depression and Anxiety Inventories (BDI-II, BAI), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Results Lower CSF A beta 42, and higher t-tau/A beta 42 and p-tau/A beta 42 ratios were associated with BDI-II and BAI total scores, clinical depression (BDI-II >= 13), and clinical anxiety (BAI >= 10), as well as NPI-Q-assessed anxiety, apathy, and nighttime behavior. Discussion CSF A beta 42, t-tau/A beta 42, and p-tau/A beta 42 ratios were associated with NPS in community-dwelling individuals free of dementia. If confirmed by a longitudinal cohort study, the findings have clinical relevance of taking into account the NPS status of individuals with abnormal CSF biomarkers.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology

Project
<a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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