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Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071088" target="_blank" >RIV/00159816:_____/19:00071088 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/19:00501556 RIV/00216224:14310/19:00109101

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.201810312" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.201810312</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/anie.201810312" target="_blank" >10.1002/anie.201810312</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway

  • Original language description

    Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound set was prepared by synthetic sequences based on chemoselective metal-mediated couplings, including assembly of the furo[3,2-b]pyridine scaffold by copper-mediated oxidative cyclization. Optimization of the subseries containing 3,5-disubstituted furo[3,2-b]pyridines afforded potent, cell-active, and highly selective inhibitors of CLKs. Profiling of the kinase-inactive subset of 3,5,7-trisubstituted furo[3,2-b]pyridines revealed sub-micromolar modulators of the Hedgehog pathway.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

    <a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Angewandte Chemie-International Edition

  • ISSN

    1433-7851

  • e-ISSN

  • Volume of the periodical

    58

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    5

  • Pages from-to

    1062-1066

  • UT code for WoS article

    000456260200017

  • EID of the result in the Scopus database