Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F21%3A00542177" target="_blank" >RIV/68081707:_____/21:00542177 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/21:00075200 RIV/00216224:14310/21:00121502
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0223523421001483?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0223523421001483?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmech.2021.113299" target="_blank" >10.1016/j.ejmech.2021.113299</a>
Alternative languages
Result language
angličtina
Original language name
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core
Original language description
The furo [3,2-b]pyridine motif represents a relatively underexplored central pharmacophore in the area of kinase inhibitors. Herein, we report flexible synthesis of 3,5-disubstituted furo [3,2-b]pyridines that relies on chemoselective couplings of newly prepared 5-chloro-3-iodofuro [3,2-b]pyridine. This methodology allowed efficient second-generation synthesis of the state-of-the-art chemical biology probe for CLK1/2/4 MU1210, and identification of the highly selective inhibitors of HIPKs MU135 and MU1787 which are presented and characterized in this study, including the X-ray crystal structure of MU135 in HIPK2. chemical biology probe (c) 2021 Published by Elsevier Masson SAS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Medicinal Chemistry
ISSN
0223-5234
e-ISSN
1768-3254
Volume of the periodical
215
Issue of the periodical within the volume
APR 5 2021
Country of publishing house
FR - FRANCE
Number of pages
8
Pages from-to
113299
UT code for WoS article
000634820600034
EID of the result in the Scopus database
2-s2.0-85101416586